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c/tirzepatide·posted 1 year ago by u/blunt_coldbox29

my ApoB moved and I cannot work out whether tirzepatide is why

Results Well Actually ×1 Slow Clap ×2 Cold Box ×3

Trying to settle this properly because the thread from last year went in circles.

The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 17 months without either producing anything.

What would actually settle it is 19 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

8,282 up / 540 down94% upvoted20 commentsid rqw9z825 May 2025

20 comments

5 in this archive, depth 3

best — the order this archive was captured in

u/kofi_balogun875 points·1 year ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/noor_hovland546 points·1 year ago

the early fullness from tirz is different, not necessarily worse

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u/vito_chowdhury590 points·1 year ago·edited

Disagree. What you are describing is consistent with SURMOUNT, not with what you concluded.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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