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c/tirzepatide·submitted 12 months ago by u/santiago_villalobos

GIP: what the trials say vs what this community says

Questionbranch of 4 comments

Confession thread, sort of. I went from 10mg to 2.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 3 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have…

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4 comments, started 12 months ago

u/elin_ferrari115 points·12 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/sofia_nascimento0 points·12 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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[removed]1 point·12 months ago

[removed by moderator]

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u/two_mil_or_one1 point·11 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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