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c/tirzepatide·posted 1 months ago by u/mikkel_ogunleye

the Zepbound question that gets asked weekly, answered properly

Side Effects Clean Column ×5

Posting this because I searched for it and got nothing useful.

Setup: 5mg, week 24, constipation present but not ruining anything. I changed exactly one variable — Mounjaro — and tracked it for 13 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

1,124 up / 274 down80% upvoted45 commentsid qcgaeq25 Jun 2026

45 comments

8 in this archive, depth 3

best — the order this archive was captured in

u/alcohol_aversion45 points·1 months ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/emil_okwuosa30 points·1 months ago

How long at each step before you escalated?

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u/curious_panel_only20 points·1 months ago

the dual agonism hits different and that is why people describe it differently

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u/sten_palacios-4 points·1 months ago

Hard agree. The food noise disappears differently on the two compounds.

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u/samir_falk1 point·1 months ago

Did the the food-noise thing feel the same as on tirz or genuinely different?

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[removed]1 point·1 months ago

[removed by moderator]

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u/rania_diallo1 point·1 months ago

week 48 on Mounjaro and the appetite profile is genuinely different from sema

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u/ingrid_correia1 point·1 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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