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c/tirzepatide·submitted 1 year ago by u/emil_barros

anyone else notice SURMOUNT kicking in around week 30

Titrationbranch of 4 comments

Trying to settle this properly because the thread from last year went in circles. The claim: SURMOUNT matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 19 months without either producing anything. What would actually settle it is 11 people measuring the same…

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4 comments, started 1 year ago

u/amara_halonen342 points·1 year ago

Switched from sema at 0.25mg to tirz at 15mg. Different drugs, cannot compare the doses directly.

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u/zaid_balogun235 points·1 year ago

Not convinced. The evidence does not support that reading.

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u/piotr_nascimento192 points·1 year ago

do not crack the pen, we have been over this

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u/incretin_ivypharmacology96 points·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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