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Single comment threadYou are looking at one branch of genuine question about dual agonist that I am slightly embarrassed to ask — 45 comments in the full submission. View in context.
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c/tirzepatide·submitted 10 months ago by u/search_before_post

genuine question about dual agonist that I am slightly embarrassed to ask

Questionbranch of 9 comments

Quick one. Canada here. 15mg works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 18 weeks and cost roughly what I expected. The admin was worse than the cost.…

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9 comments, started 10 months ago
u/customs_seizure_sid113 points·10 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/aksel_kjaer166 points·10 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

Disagree on that part. 98.4% and 98.3% on the same vial is normal.

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u/crosspost_bot_no81 points·10 months ago·edited

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/noor_hovland63 points·10 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/search_before_postOP90 points·10 months ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/line_petrov50 points·10 months ago

Disagree. What you are describing is consistent with 15mg, not with what you concluded.

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u/hub_opssite staff33 points·10 months ago

Hard agree. The food noise disappears differently on the two compounds.

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u/rania_marchand0 points·10 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/piotr_nascimento27 points·10 months ago

the dual agonism hits different and that is why people describe it differently

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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