[Question] SURPASS — what am I missing here
Right, the Mounjaro question again, but with numbers this time.
I have 2 data points over 40 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.
The thing I would flag for anyone new: the effect I am describing showed up at week 75, not week 29. People give up long before the interesting part.
Interested in whether this matches other people's logs or whether I am an outlier.
best — the order this archive was captured in
Disagree. What you are describing is consistent with Zepbound, not with what you concluded.
Hard agree. The food noise disappears differently on the two compounds.
This matches the trial data. SURMOUNT-1 was 94.2% body weight at 24 weeks.
the GIP side does different things than the GLP-1 side, that is the point
do not crack the pen, we have been over this
the appetite change on tirz is more than just reduced hunger, it is different machinery
the dual agonism hits different and that is why people describe it differently
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
SURMOUNT data is messier than STEP data but the weight loss is there
the 15mg is the top of the pen, not the required dose
The dual agonism story is real. The appetite is physically different from semaglutide alone.
Not to be pedantic but Mounjaro and tirzepatide are being used interchangeably and they are not interchangeable in real life.
- 1Hard agree. The food noise disappears differently on the two compounds.8 comments in this branch · started by u/mikkel_kimani