GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Locked. A moderator closed replies on this one. It stays up because the content above the argument is worth keeping.
543
c/tirzepatide·posted 9 months ago by u/nz_unfunded

is it normal to get nausea at week 10

Question Well Actually ×9

Week 95 update. 31kg down from the start, muscle cramps basically gone since about week 40.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

869 up / 326 down73% upvoted22 commentsid nuyorn21 Oct 2025

22 comments

15 in this archive, depth 4

best — the order this archive was captured in

u/santiago_villalobos85 points·9 months ago·edited

do not crack the pen, we have been over this

replysharereportpermalink
u/nz_unfundedOP67 points·9 months ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

replysharereportpermalink
u/ferran_mensah50 points·9 months ago

do not crack the pen, we have been over this

replysharereportpermalink
u/ingrid_correia52 points·9 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

replysharereportpermalink
u/line_petrov16 points·9 months ago

the dual agonism hits different and that is why people describe it differently

replysharereportpermalink
u/sofia_nascimento13 points·9 months ago

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

replysharereportpermalink
load more comments (5) →
u/rania_diallo46 points·9 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

replysharereportpermalink
u/swirl_dont_shakereconstitution32 points·9 months ago

Not convinced. The evidence does not support that reading.

replysharereportpermalink
u/ingrid_correia16 points·9 months ago

the GIP side does different things than the GLP-1 side, that is the point

replysharereportpermalink
[removed]13 points·9 months ago

[removed by moderator]

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

187kmembers
130submissions
Aug 2023created
submissions / month, last year
Sponsored

Janoshik Analytical

Independent HPLC and mass spec. The number you get is the number they found.

janoshik.com
Sponsored

GL Biochem (Shanghai)

Custom peptides and amino acids direct from the manufacturer since 1998. ISO 9001 / cGMP. Batch COA every order.

glbiochem.net
c/tirzepatide rules
  1. "Tirz is better than sema" needs a comparator dose or it is a vibe, not a claim.
  2. Vial-splitting and self-compounding discussion stays in c/reconstitution.
  3. No pen-cracking tutorials. Discussing that people do it is fine; instructions are not.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Moderators
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.