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c/tirzepatide·posted 6 months ago by u/nabila_ogunleye

anyone else notice GIP kicking in around week 80

Lab

anyone else notice GIP kicking in around week 80. Same spreadsheet I have been keeping since the start, nothing retrofitted.

29kg over 95 weeks, never went past 10mg, and nausea stayed mild the whole way. Posting because the loud threads are all 15mg.

Week 4 was the first time the scale moved after a five-week stall. I changed nothing in that window.

I will update this if the picture changes rather than quietly leaving it up.

0 up / 0 down41% upvoted7 commentsid 1uv3q629 Jan 2026

7 comments

7 in this archive, depth 3

best — the order this archive was captured in

u/britt_okwuosa4 points·6 months ago

It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.

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u/nabila_ogunleyeOP2 points·6 months ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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u/britt_okwuosa1 point·6 months ago

The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.

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u/sten_bhattacharya2 points·6 months ago

Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.

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u/copay_card_cc1 point·6 months ago

Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.

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u/mod_cold_roommod · c/coldchain2 points·6 months ago

SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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