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c/tirzepatide·posted 7 months ago by u/zaid_balogun

[Meta] proposal — a flair for Zepbound posts

Lab Long Haul ×7 Slow Clap ×3 The Quiet One ×3

Genuinely asking, not being difficult.

Everyone in c/bloodwork repeats that GIP is important. I believe it, but I have never seen anyone show why, and when I search I get 15 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

6,098 up / 381 down94% upvoted33 commentsid 1th5pp24 Dec 2025

33 comments

12 in this archive, depth 4

best — the order this archive was captured in

u/hugo_bergstrom380 points·7 months ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/forest_plot_fionastats560 points·7 months ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/hugo_bergstrom388 points·7 months ago

Cosigning.

Adding to this: SURPASS is doing more work than the comment implies.

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u/bastian_eriksen255 points·7 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/zaid_balogunOP160 points·7 months ago

Did you stay on semaglutide or switch? The outcome is different if you are comparing.

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u/search_before_post99 points·7 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/bastian_eriksen270 points·7 months ago·edited

the GIP side does different things than the GLP-1 side, that is the point

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u/b12_baseline68 points·7 months ago·edited

The confident tone is doing a lot of work that the evidence is not.

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u/matias_salgado19 points·7 months ago

dual agonism is dual agonist, do not generalise from semaglutide

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u/quiet_moderatorMOD265 points·7 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/dario_vermeulen401 points·7 months ago

the reflux from tirz is different, not necessarily worse

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u/zaid_balogunOP231 points·7 months ago

My TSH moved faster on tirz than on sema at the same timepoint, which matches what people report.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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