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c/tirzepatide·submitted 4 months ago by u/piotr_nascimento

SURMOUNT — my 11-week log, condensed into one table

Titrationbranch of 6 comments

Been lurking in c/orforglipron for about 12 months and finally have something worth posting. Short version: week 3, 5mg, and dual agonist is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 37 threads, and the answers split roughly down the middle. What I actually want to…

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6 comments, started 4 months ago
u/discount_math_dm24 points·4 months ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/piotr_nascimentoOP18 points·4 months ago

My eGFR moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/slow_logbook_ftw14 points·4 months ago·edited

My eGFR moved faster on tirz than on sema at the same timepoint, which matches what people report.

Disagree on that part. 98.1% and 97.6% on the same vial is normal.

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u/piotr_nascimento3 points·4 months ago

Small correction: the trial was 4 weeks, not 32. Does not change your point but people will quote it.

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u/gustav_vermeulen8 points·4 months ago·edited

the early fullness from tirz is different, not necessarily worse

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u/rania_marchand-23 points·4 months ago

I love that this community will spend 40 comments on a detail.

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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