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c/tirzepatide·submitted 5 months ago by u/thyroid_tangent

what changed for me between week 5 and week 48

Questionbranch of 10 comments

Confession thread, sort of. I went from 0.5mg to 12.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 16 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have early…

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10 comments, started 5 months ago
u/georgi_chowdhury-11 points·5 months ago

Respectfully this is a sample of one presented as a finding.

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[removed]1 point·5 months ago

[removed by moderator]

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u/halima_boateng1 point·5 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/sofia_nascimento1 point·5 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

Disagree on that part. 98.1% and 97.9% on the same vial is normal.

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u/halima_boateng1 point·5 months ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/thyroid_tangentOP1 point·5 months ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/spain_receta1 point·5 months ago

week 92 on Mounjaro and the appetite profile is genuinely different from sema

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u/matias_salgado1 point·5 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/certified_referenceQC1 point·5 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/ignacio_vanhecke1 point·5 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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