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c/tirzepatide·submitted 2 years ago by u/neha_falk

[Discussion] we are measuring Zepbound at the wrong time and calling it noise

Discussionbranch of 10 comments

Posting this because I searched for it and got nothing useful. Setup: 2.5mg, week 84, sulphur burps present but not ruining anything. I changed exactly one variable — Mounjaro — and tracked it for 9 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I…

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10 comments, started 2 years ago
u/halima_boateng139 points·2 years ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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u/hub_opssite staff114 points·2 years ago

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

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u/georgi_chowdhury74 points·2 years ago

the 15mg is the top of the pen, not the required dose

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u/sofia_nascimento40 points·2 years ago·edited

You have restated the marketing copy. What is the actual substance here.

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u/ghrp_history48 points·2 years ago

the fatigue from tirz is different, not necessarily worse

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u/two_mil_or_one36 points·2 years ago

Did the constipation feel the same as on tirz or genuinely different?

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u/throwaway_titration-26 points·2 years ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/kofi_balogun1 point·2 years ago

That is net peptide content, not purity. Different number, different meaning.

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u/elin_ferrari33 points·2 years ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/nz_unfunded77 points·2 years ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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