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c/tapering·posted 1 year ago by u/valeria_girard

my A1c moved and I cannot work out whether interval stretching is why

Question Clean Column ×6 Slow Clap ×2

Right, the appetite return question again, but with numbers this time.

I have 23 data points over 36 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 33, not week 82. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

1,949 up / 70 down97% upvoted60 commentsid if3vy916 Jul 2025

60 comments

26 in this archive, depth 5

best — the order this archive was captured in

u/janek_ferrari228 points·1 year ago

the people who came off and restarted without shame

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u/arne_amankwah174 points·1 year ago

the people who came off and restarted without shame

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/micro_bump_mick-26 points·1 year ago

interval stretching versus dose reduction

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u/ismael_varga94 points·1 year ago

Strongly agree. The regain is expected.

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u/chidi_vermeulen267 points·1 year ago

cite the discontinuation data rather than guessing regain rates

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u/taper_off_tabithaMOD130 points·1 year ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/appeal_letter_al101 points·1 year ago

the 11 week discontinuation arm is the data

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u/ismael_varga39 points·1 year ago

Yeah, regain is not a failure.

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[removed]72 points·1 year ago

[removed by moderator]

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u/adaeze_weiss98 points·1 year ago

This is correct. Discontinuation data is real.

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u/valeria_girardOP72 points·1 year ago

Stalled for 12 weeks, changed nothing, and it started moving again on week 86.

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u/valeria_girardOP58 points·1 year ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/dario_stanescu21 points·1 year ago·edited

Stalled for 12 weeks, changed nothing, and it started moving again on week 86.

Adding to this: appetite return is doing more work than the comment implies.

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u/quarter_dose_queenlow and slow13 points·1 year ago

That is net peptide content, not purity. Different number, different meaning.

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u/valeria_girardOP5 points·1 year ago

That is net peptide content, not purity.

Disagree on that part. 98.1% and 98.3% on the same vial is normal.

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u/skip_week_sceptic39 points·1 year ago

no shaming people who restart

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u/adaeze_weiss12 points·1 year ago

Yeah, regain is not a failure.

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u/ignacio_silva54 points·1 year ago

Yeah, regain is not a failure.

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u/appeal_letter_al17 points·1 year ago

Second this question. I have wondered about regain for 18 months and never seen a straight answer.

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u/ignacio_silva14 points·1 year ago

This is correct. Discontinuation data is real.

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u/hana_lehtinen11 points·1 year ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/patient_labslip_log8 points·1 year ago

tapering instructions are not welcome here

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u/border_paperwork19 points·1 year ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/neha_krastev0 points·1 year ago

say how long you were on and at what dose before taper

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u/appeal_letter_al54 points·1 year ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/nora_ramos45 points·1 year ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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