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c/tapering·posted 5 months ago by u/patient_labslip_log

[Question] the UK — has anyone got a straight answer on appetite return

Question Cold Box ×2 The Quiet One ×3

tapering. That is the whole post, but I will justify it.

Everything else people worry about in c/glp1eu is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort tapering out first, and almost nobody does.

I say this having got it wrong for 24 months. My hs-CRP was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

1,367 up / 141 down91% upvoted32 commentsid 1iru4t14 Feb 2026

32 comments

23 in this archive, depth 6

best — the order this archive was captured in

u/hana_lehtinen80 points·5 months ago

Strongly agree. The regain is expected.

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u/yara_bakken26 points·5 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/nayeli_fonseca73 points·5 months ago

This is correct. Discontinuation data is real.

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u/adaeze_brandt55 points·5 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/patient_labslip_logOP54 points·5 months ago

coming off deliberately, not by accident

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u/aleksi_lehtinen38 points·5 months ago

regain on taper is expected, plan for it

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u/jarno_adebayo19 points·5 months ago

no shaming people who restart

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u/patient_labslip_logOP10 points·5 months ago

Stalled for 10 weeks, changed nothing, and it started moving again on week 90.

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[deleted]13 points·5 months ago

[deleted]

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u/rina_bergstrom8 points·5 months ago

regain on taper is expected, plan for it

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u/naomi_ekstrom3 points·5 months ago

appetite return timelines vary tapering

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u/preservative_free_p-4 points·5 months ago

regain on taper is expected, plan for it

Adding to this: interval stretching is doing more work than the comment implies.

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u/marta_dziedzic1 point·5 months ago

the people who came off and restarted without shame

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u/marta_weiss13 points·5 months ago

Maintenance for 10 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/aleksi_lehtinen11 points·5 months ago·edited

appetite return timelines vary appetite return

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u/rafael_sjoberg33 points·5 months ago

coming off deliberately, not by accident

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u/marta_marchand18 points·5 months ago

coming off deliberately, not by accident

Disagree on that part. 97.9% and 97.6% on the same vial is normal.

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u/marta_marchand6 points·5 months ago·edited

say how long you were on and at what dose before taper

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u/patient_labslip_logOP8 points·5 months ago

Yeah, regain is not a failure.

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u/maintenance_mode_maxMOD13 points·5 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/janek_ferrari8 points·5 months ago

Tracking number removed.

Yes, exactly this, and it is the bit that took me 24 weeks to accept.

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u/nikhil_lindqvist18 points·5 months ago

Strongly agree. The regain is expected.

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u/britta_boateng19 points·5 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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