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c/tapering·submitted 1 months ago by u/ismael_eriksen

[Discussion] appetite return is doing more work than we give it credit for

Discussionbranch of 6 comments

Genuinely asking, not being difficult. Everyone in c/bloodwork repeats that interval stretching is important. I believe it, but I have never seen anyone show why, and when I search I get 20 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is…

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6 comments, started 1 months ago
u/vikram_asante60 points·1 months ago

regain on taper is expected, plan for it

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u/maintenance_mode_maxMOD30 points·1 months ago

Retitled to remove editorialising. Put the evidence in the body.

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[deleted]13 points·1 months ago

[deleted]

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u/nikhil_lindqvist-7 points·1 months ago

appetite return timelines vary tapering

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u/salma_vasquez10 points·1 months ago

appetite return timelines vary interval stretching

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u/ismael_eriksenOP44 points·1 months ago

Came off after 69 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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