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c/tapering·submitted 1 months ago by u/coa_janitor

interval stretching is the most under-discussed thing in c/t2dglp1

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Right, the appetite return question again, but with numbers this time. I have 10 data points over 28 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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6 comments, started 1 months ago
u/taper_off_tabithaMOD33 points·1 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/ahmed_cardoso27 points·1 months ago

the people who came off and restarted without shame

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u/source_or_silence18 points·1 months ago

cite the discontinuation data rather than guessing regain rates

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[deleted]8 points·1 months ago

[deleted]

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u/aleksi_lehtinen13 points·1 months ago

Small correction: the trial was 20 weeks, not 29. Does not change your point but people will quote it.

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u/ilias_kaufmann19 points·1 months ago

Strongly agree. The regain is expected.

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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