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c/tapering·posted 1 months ago by u/coa_janitor

interval stretching is the most under-discussed thing in c/t2dglp1

Regain Receipts ×6

Right, the appetite return question again, but with numbers this time.

I have 10 data points over 28 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 63, not week 17. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

514 up / 53 down91% upvoted27 commentsid 1ds4fu27 Jun 2026

27 comments

22 in this archive, depth 4

best — the order this archive was captured in

u/naomi_ekstrom96 points·1 months ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/nora_ramos22 points·1 months ago

Strongly agree. The regain is expected.

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u/neha_krastev58 points·1 months ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/vikram_ferreira15 points·1 months ago

appetite return timelines vary interval stretching

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u/preservative_free_p54 points·1 months ago

Strongly agree. The regain is expected.

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u/coa_janitorOPmod · c/coa79 points·1 months ago

Strongly agree.

Adding to this: regain is doing more work than the comment implies.

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u/coa_janitorOPmod · c/coa-4 points·1 months ago

Did anything else change in the same window?

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u/taper_off_tabitha1 point·1 months ago

no shaming people who restart

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u/taper_off_tabithaMOD33 points·1 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/ahmed_cardoso27 points·1 months ago

the people who came off and restarted without shame

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u/source_or_silence18 points·1 months ago

cite the discontinuation data rather than guessing regain rates

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[deleted]8 points·1 months ago

[deleted]

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u/aleksi_lehtinen13 points·1 months ago

Small correction: the trial was 20 weeks, not 29. Does not change your point but people will quote it.

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u/ilias_kaufmann19 points·1 months ago

Strongly agree. The regain is expected.

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u/ahmed_cardoso22 points·1 months ago

Week 64 for me and the honest summary is: 35kg down, fatigue manageable, and I have thought about food maybe four times today.

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u/coa_janitorOPmod · c/coa16 points·1 months ago

Stalled for 22 weeks, changed nothing, and it started moving again on week 27.

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u/zeynep_zielinski17 points·1 months ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/fabio_lehtinen11 points·1 months ago

appetite return timelines vary tapering

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u/taper_off_tabitha16 points·1 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/yara_bakken12 points·1 months ago

the people who came off and restarted without shame

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u/zeynep_ndiaye11 points·1 months ago

Ireland here. Waited 15 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/anders_kuusela6 points·1 months ago

Ireland here.

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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