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c/survodutide·posted 8 months ago by u/old_account_2023

the MASH question that gets asked weekly, answered properly

Paper

Trying to settle this properly because the thread from last year went in circles.

The claim: MASH matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 10 months without either producing anything.

What would actually settle it is 7 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

172 up / 233 down42% upvoted12 commentsid v79ye06 Nov 2025

12 comments

12 in this archive, depth 4

best — the order this archive was captured in

u/jarno_adeyemi0 points·8 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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[removed]1 point·8 months ago

[removed by moderator]

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u/britt_okwuosa1 point·8 months ago

phase 13 data is interesting, phase 5 will be different

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u/heart_rate_bump1 point·8 months ago

MASH claims need the trial and the biopsy endpoint

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u/camila_trevino11 points·8 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/nadia_bakker9 points·8 months ago·edited

rodent survodutide is investigation only

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u/renzo_asante5 points·8 months ago

not approved, descriptive posts only

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u/slow_logbook_notes302 points·8 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/patient_labslip_log7 points·8 months ago
well that is my evening gone, thanks for the paper
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u/liver_enzyme_lizMOD5 points·8 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/old_account_2023OP0 points·8 months ago

Strongly agree. The safety story is separate.

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u/old_account_2023OP1 point·8 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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