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c/survodutide·posted 4 months ago by u/thermal_mass_tom

biopsy is the most under-discussed thing in c/bloodwork

Question Clean Column ×5 Sourced ×1

Something I noticed reading old threads that I have not seen said out loud.

The advice on hepatic fat in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

1,411 up / 70 down95% upvoted64 commentsid 1xhu9m19 Mar 2026

64 comments

26 in this archive, depth 6

best — the order this archive was captured in

u/border_paperwork231 points·4 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/kaia_cabrera183 points·4 months ago

the safety profile is not just tirzepatide amplified

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u/rania_marchand114 points·4 months ago

The constipation was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/lyophile_lou166 points·4 months ago

the MASH indication changes the risk calculus

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u/andres_dahlberg104 points·4 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/nadia_bakker57 points·4 months ago

Yeah, glucagon co-agonism is genuinely different.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/andres_dahlberg42 points·4 months ago

the GLP-1/glucagon dual is glucagon, different from GIP/GLP-1

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u/thermal_mass_tomOP61 points·4 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/dario_boateng61 points·4 months ago

phase 11 data is interesting, phase 25 will be different

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u/britt_okwuosa-34 points·4 months ago

I am going to push back on this slightly.

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u/milos_mensa1 point·4 months ago

the heart rate signal is real in the data

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u/marisol_frisk52 points·4 months ago

phase 16 data is interesting, phase 24 will be different

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u/thermal_mass_tomOP21 points·4 months ago

phase 16 data is interesting, phase 24 will be different

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/julia_mensa6 points·4 months ago

rodent dual agonist is investigation only

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[deleted]20 points·4 months ago

[deleted]

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u/incretin_ivyMOD39 points·4 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/whois_wanda24 points·4 months ago

the MASH indication changes the risk calculus

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u/kian_ferreira17 points·4 months ago

glucagon co-agonism has a different safety story

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u/peak_area_peteanalytical6 points·4 months ago·edited

Which trial arm?

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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