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c/survodutide·submitted 4 months ago by u/thermal_mass_tom

biopsy is the most under-discussed thing in c/bloodwork

Questionbranch of 6 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on hepatic fat in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers…

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6 comments, started 4 months ago
u/rania_marchand114 points·4 months ago

The constipation was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/lyophile_lou166 points·4 months ago

the MASH indication changes the risk calculus

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u/andres_dahlberg104 points·4 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/nadia_bakker57 points·4 months ago

Yeah, glucagon co-agonism is genuinely different.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/andres_dahlberg42 points·4 months ago

the GLP-1/glucagon dual is glucagon, different from GIP/GLP-1

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u/thermal_mass_tomOP61 points·4 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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