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c/sideeffects·posted 10 months ago by u/blunt_coldbox_2024

my hs-CRP moved and I cannot work out whether gallbladder is why

Resolved Long Haul ×8 Sourced ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking nausea against ApoB for 27 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

2,093 up / 378 down85% upvoted65 commentsid dgwsj012 Sep 2025

65 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/mass_spec_maggieMS129 points·10 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/aa_analysis_andy75 points·10 months ago

week 16 and the injection-site soreness is finally getting better

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u/sofia_wikstrom60 points·10 months ago

week 16 and the injection-site soreness is finally getting better

Adding to this: heart rate is doing more work than the comment implies.

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u/blunt_coldbox_2024OP32 points·10 months ago

early fullness at 1.7mg is different from 1.0mg

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u/elin_trevino76 points·10 months ago

resting heart rate moved up 10 bpm and settled back down when I stopped escalating

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u/marta_marchand52 points·10 months ago

Yeah, the constipation hit on day 5 for me too, not day 1.

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u/britt_abubakar58 points·10 months ago

severe abdominal pain is an urgent-care question, not a forum question

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u/janoshik_junkieindependent tester39 points·10 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/halima_mbeki18 points·10 months ago·edited

week 26 and the the food-noise thing is finally getting better

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u/blunt_coldbox_2024OP13 points·10 months ago

My the food-noise thing was worst at 2.4mg and better at 0.5mg, which makes no sense but it is real.

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u/saskia_lokken4 points·10 months ago

sulphur burps are disgusting but not dangerous, 11 weeks and they stopped

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u/constipation_clubMOD22 points·10 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/chidi_abubakar15 points·10 months ago

week 93 and the nausea is finally getting better

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u/elin_lindqvist5 points·10 months ago

Did the fatigue start before or after the dose increase?

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u/halima_mbeki22 points·10 months ago

week 41 and the injection-site soreness is finally getting better

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u/saskia_lokken-21 points·10 months ago

Strongly agree. Describe your dose, your week number, and your titration speed or nobody can help.

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u/fibre_forward1 point·10 months ago

The fatigue was genuinely awful for three weeks and then simply stopped. Week 8 me did not think I would make it to week 57.

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u/insulin_syringe_ian0 points·10 months ago

the muscle cramps passes. i promise. not medical advice.

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u/sequence_checkerresearch peptides1 point·10 months ago

sulphur burps are disgusting but not dangerous, 23 weeks and they stopped

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u/step_therapy_s1 point·10 months ago

Not to be pedantic but gallbladder and fatigue are being used interchangeably and they are not interchangeable in real life.

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u/iman_castellanos1 point·10 months ago

The fatigue was genuinely awful for three weeks and then simply stopped.

Disagree on that part. 97.4% and 98.7% on the same vial is normal.

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u/blunt_coldbox_2024OP1 point·10 months ago

severe abdominal pain is an urgent-care question, not a forum question

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u/marta_marchand1 point·10 months ago

hair loss is real and usually reversible when you stabilize

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u/ayesha_erdogan1 point·10 months ago

Strongly agree. Describe your dose, your week number, and your titration speed or nobody can help.

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u/chidi_abubakar1 point·10 months ago·edited

hair loss is real and usually reversible when you stabilize

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u/yannick_barros1 point·10 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/clara_weiss14 points·10 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/adnan_karlsen10 points·10 months ago

How many weeks in are you? 5 weeks is noise, 12 weeks is a trend.

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Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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