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c/reconstitution·posted 2 years ago by u/elin_ferrari

why does nobody talk about reconstitution

PSA Well Actually ×8 Long Haul ×3

Trying to settle this properly because the thread from last year went in circles.

The claim: mg/mL matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 9 months without either producing anything.

What would actually settle it is 13 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

1,664 up / 511 down77% upvoted39 commentsid 1jjnjf11 Nov 2023

39 comments

26 in this archive, depth 5

best — the order this archive was captured in

u/swirl_dont_shakereconstitution160 points·2 years ago
i have this exact spreadsheet
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u/rosa_mensah101 points·2 years ago

Cosigning. The concentration on the vial in marker is load-bearing.

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u/tl_dr_tina81 points·2 years ago·edited

Cosigning.

Disagree on that part. 97.4% and 97.6% on the same vial is normal.

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u/ilias_steiner52 points·2 years ago·edited

bacteriostatic and sterile water are not interchangeable, do not use them that way

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u/units_not_mgMOD160 points·2 years ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/clara_weiss71 points·2 years ago·edited

bacteriostatic and sterile water are not interchangeable, do not use them that way

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u/elin_ferrariOP87 points·2 years ago

Slight fix: the number was 99.0, not 98.9. Decimal point, but a fairly consequential one.

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u/tomas_kimani87 points·2 years ago

Removed a chain here.

Disagree on that part. 98.4% and 98.3% on the same vial is normal.

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u/viktor_erdogan-6 points·2 years ago

show your working or it is unhelpful

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u/arne_restrepo84 points·2 years ago
genuinely useful, thanks
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u/tl_dr_tina56 points·2 years ago

bacteriostatic and sterile water are not interchangeable, do not use them that way

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u/aurel_boateng52 points·2 years ago
yep. 74 weeks in, same.
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u/yusuf_achebe36 points·2 years ago

What was the vial size and how much bac water?

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u/elin_ferrariOP34 points·2 years ago

Two vials, two different concentrations, forgot which was which, almost made a 4 times error. Now I label everything.

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u/bruno_dumitru10 points·2 years ago·edited

i am begging people to write down the concentration

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u/reflux_report8 points·2 years ago·edited

Yeah, showing the arithmetic is the fastest way for someone to spot the error.

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u/elin_ferrariOP4 points·2 years ago

i am begging people to write down the concentration

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[removed]6 points·2 years ago

[removed by moderator]

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u/marisol_frisk54 points·2 years ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/priya_weiss20 points·2 years ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/swirl_dont_shakereconstitution15 points·2 years ago

never post a calculation as advice without stating the concentration

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u/rosa_mensah12 points·2 years ago

more water means more units for the same dose, which means finer resolution

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u/viktor_kirchner7 points·2 years ago

swirl, do not shake, or you are courting oxidation

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u/iman_falk33 points·2 years ago

That is net peptide content, not purity. Different number, different meaning.

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u/saskia_mwangi23 points·2 years ago

stopper coring on the 8th draw because you keep using the same entry point. rotate.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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