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1.8k

switched from 0.25mg to 15mg and the injection-site soreness got better, not worse

Math Cold Box ×1 Slow Clap ×3

Posting this because I searched for it and got nothing useful.

Setup: 1.0mg, week 49, sulphur burps present but not ruining anything. I changed exactly one variable — insulin syringe — and tracked it for 3 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

1,982 up / 201 down91% upvoted40 commentsid 15hs5h2 Nov 2024

40 comments

25 in this archive, depth 4

best — the order this archive was captured in

u/honest_syringe_maybe167 points·1 year ago
genuinely useful, thanks
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u/signe_grimaldi45 points·1 year ago

dosing errors come from people reconstituting two vials differently and forgetting which is which

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u/anya_antonsen75 points·1 year ago

This is correct. 2mL versus 22mL is the common mistake.

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u/julia_erdogan-17 points·1 year ago

stopper coring on the 19th draw because you keep using the same entry point. rotate.

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u/nadia_kjaer112 points·1 year ago

swirl, do not shake, or you are courting oxidation

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u/anya_antonsen134 points·1 year ago

Are you using a u-100 or u-40 syringe? That changes everything.

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u/bruno_dumitru46 points·1 year ago

Are you using a u-100 or u-40 syringe?

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/britta_nakamuraOP78 points·1 year ago

swirl, do not shake, or you are courting oxidation

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u/oskar_ibarra38 points·1 year ago

Is that 30mg vial or 13mg?

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u/units_not_mgMOD82 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/anjali_tamm35 points·1 year ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/tomas_kimani12 points·1 year ago·edited

30mg vial, 2mL water, concentration is 30/2 — write it on the vial afterwards

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u/escrow_evangelist27 points·1 year ago·edited

dead space is real and the syringe matters

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u/reflux_report21 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/a1c_arcT2D7 points·1 year ago

stopper coring on the 12th draw because you keep using the same entry point. rotate.

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u/arto_falk60 points·1 year ago

Spent 3 weeks confused about concentration math until someone showed me the table. 10mg, 1mL, concentration is 10/1.

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u/janek_ferrari32 points·1 year ago

Dead space ate 22 units on a low-volume draw. Tiny impact at 15mg, massive impact at 0.5mg.

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u/vito_beaulieu16 points·1 year ago

Is that 30mg vial or 26mg?

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u/kavya_radich5 points·1 year ago·edited

dosing errors come from people reconstituting two vials differently and forgetting which is which

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u/marisol_frisk13 points·1 year ago

u-100 syringe, not u-40, or your math is off by factor of 14

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u/britta_nakamuraOP8 points·1 year ago

more water means more units for the same dose, which means finer resolution

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u/priya_guerrero18 points·1 year ago

show your working or it is unhelpful

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u/britta_nakamura17 points·1 year ago·edited

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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