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Single comment threadYou are looking at one branch of someone explain bacteriostatic water to me like I have not read a paper in years — 35 comments in the full submission. View in context.
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c/reconstitution·submitted 1 year ago by u/declared_value_dv

someone explain bacteriostatic water to me like I have not read a paper in years

PSAbranch of 9 comments

Trying to settle this properly because the thread from last year went in circles. The claim: reconstitution matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 11 months without either producing anything. What would actually settle it is 11 people measuring the…

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This branch

9 comments, started 1 year ago
u/saskia_mwangi243 points·1 year ago

This is correct. 1mL versus 9mL is the common mistake.

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u/rasmus_mensah170 points·1 year ago

5mg vial, 1mL water, concentration is 5/1 — write it on the vial afterwards

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u/RetaAndRegret275 points·1 year ago

swirl, do not shake, or you are courting oxidation

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u/declared_value_dvOP44 points·1 year ago

swirl, do not shake, or you are courting oxidation

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/hub_opssite staff54 points·1 year ago

show your working or it is unhelpful

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u/escrow_evangelist197 points·1 year ago·edited

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/declared_value_dvOP0 points·1 year ago

Cored the stopper on my 18th draw because I kept using the same entry point. Rotate the puncture site.

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u/units_not_mgsyringe math84 points·1 year ago

never post a calculation as advice without stating the concentration

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u/honest_syringe_maybe68 points·1 year ago

more water means more units for the same dose, which means finer resolution

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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