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c/reconstitution·posted 1 year ago by u/hedda_adeyemi

[Discussion] reconstitution is doing more work than we give it credit for

Discussion

Trying to settle this properly because the thread from last year went in circles.

The claim: insulin syringe matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything.

What would actually settle it is 13 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

258 up / 12 down96% upvoted23 commentsid 13jy3431 Mar 2025

23 comments

17 in this archive, depth 4

best — the order this archive was captured in

u/rasmus_mensah29 points·1 year ago

10mg vial, 2mL water, concentration is 10/2 — write it on the vial afterwards

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u/priya_weiss27 points·1 year ago

Dead space ate 11 units on a low-volume draw. Tiny impact at 2.5mg, massive impact at 15mg.

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u/batch_number_bertievetting12 points·1 year ago

Not convinced. The evidence does not support that reading.

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u/emil_zamora8 points·1 year ago

never post a calculation as advice without stating the concentration

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u/signe_grimaldi12 points·1 year ago

Cosigning. The concentration on the vial in marker is load-bearing.

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u/quarter_dose_queenlow and slow-11 points·1 year ago

Reconstituted at 2mL when I meant 24mL. Caught it because the units looked wrong. Write the concentration.

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u/swirl_dont_shakeMOD10 points·1 year ago

Tracking number removed. It identifies both ends of a shipment.

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u/freya_onwuka8 points·1 year ago

swirl, do not shake, or you are courting oxidation

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u/tuva_kirchner3 points·1 year ago

Respectfully this is a sample of one presented as a finding.

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[deleted]1 point·1 year ago

[deleted]

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u/niels_roos9 points·1 year ago

Cosigning. The concentration on the vial in marker is load-bearing.

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u/ilias_steiner5 points·1 year ago

Cosigning. The concentration on the vial in marker is load-bearing.

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u/saskia_rahimi4 points·1 year ago

Cosigning.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/runa_cabrera3 points·1 year ago

That is net peptide content, not purity. Different number, different meaning.

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u/hedda_adeyemiOP1 point·1 year ago

dead space is real and the syringe matters

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u/emil_zamora1 point·1 year ago

show your working or it is unhelpful

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u/kenji_kimani3 points·1 year ago

Not convinced. The evidence does not support that reading.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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