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c/orforglipron·submitted 3 months ago by u/marit_sandvik

non-peptide: what the trials say vs what this community says

Discussionbranch of 7 comments

Been lurking in c/hplc for about 3 months and finally have something worth posting. Short version: week 49, 5mg, and oral GLP-1 is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 7 threads, and the answers split roughly down the middle. What I actually want to know is…

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7 comments, started 2 months ago
u/trialwatch_theotrial nerd10 points·2 months ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/cloudy_vial_carol3 points·2 months ago

availability speculation must be flaired Speculation

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u/whois_wanda1 point·2 months ago

Slight fix: the number was 97.6, not 98.3. Decimal point, but a fairly consequential one.

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u/marit_sandvikOP1 point·2 months ago

The fatigue was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/quiet_moderatormod8 points·2 months ago·edited

cite ATTAIN/ACHIEVE arms specifically

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u/chidi_yilmaz4 points·2 months ago

cite ATTAIN/ACHIEVE arms specifically

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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