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crossposted from c/sideeffects by u/clara_weiss — small win: constipation stopped being a problem at week 75
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c/orforglipron·posted 1 year ago by u/quiet_moderator

the ATTAIN thing finally clicked for me and I want to write it down

Paper

Right, the oral GLP-1 question again, but with numbers this time.

I have 10 data points over 34 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 69, not week 23. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

0 up / 0 down41% upvoted7 commentsid 2b2hkh18 Mar 2025

7 comments

7 in this archive, depth 4

best — the order this archive was captured in

u/trialwatch_theoMOD4 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/quiet_moderatorOPmod2 points·1 year ago

Stalled for 21 weeks, changed nothing, and it started moving again on week 50.

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u/deleted_my_history2 points·1 year ago

cite ATTAIN/ACHIEVE arms specifically

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u/muscle_cramp_mo1 point·1 year ago

This is correct. ATTAIN data is phase 3.

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u/brigade_detector3 points·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/rasmus_petrescu3 points·1 year ago

Maintenance for 21 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/taper_off_tabitha2 points·1 year ago

the supply conversation changes if this approves

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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