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c/orforglipron·submitted 2 years ago by u/search_before_post

unpopular opinion: small molecule is massively overrated

Speculationbranch of 8 comments

Posting this because I searched for it and got nothing useful. Setup: 10mg, week 47, constipation present but not ruining anything. I changed exactly one variable — non-peptide — and tracked it for 19 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I…

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8 comments, started 2 years ago
u/marit_sandvik-21 points·2 years ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/search_before_postOP1 point·2 years ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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[deleted]1 point·2 years ago

[deleted]

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u/santiago_villalobos1 point·2 years ago

ATTAIN and ACHIEVE are phase 3 trials

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u/soren_yildiz1 point·2 years ago

the ACHIEVE is whether this actually works long-term

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u/dilara_weiss1 point·2 years ago

small molecule purity is different testing than peptides

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u/scam_taxonomyc/scamalerts0 points·2 years ago

Disagree. What you are describing is consistent with orforglipron, not with what you concluded.

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u/soren_yildiz1 point·2 years ago

That is net peptide content, not purity. Different number, different meaning.

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