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c/orforglipron·submitted 1 months ago by u/kavya_radich

[Discussion] non-peptide is doing more work than we give it credit for

Discussionbranch of 8 comments

Week 24 update. 25kg down from the start, reflux basically gone since about week 76. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux. The part that surprised me is how much of this is admin. Ordering,…

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8 comments, started 1 months ago
u/ravi_sandvik17 points·1 months ago

cite ATTAIN/ACHIEVE arms specifically

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u/bastian_ekstrom11 points·1 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/kavya_radichOP8 points·29 days ago

ATTAIN and ACHIEVE are phase 16 trials

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u/bruno_dumitru7 points·29 days ago

small molecule purity is different testing than peptides

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u/kavya_radichOP3 points·29 days ago

the UK here. Waited 8 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/fasting_insulin_f8 points·1 months ago

cite ATTAIN/ACHIEVE arms specifically

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/kavya_radichOP10 points·1 months ago

Came off after 64 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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