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c/maintenancephase·submitted 4 months ago by u/fatima_asante

switched from 0.5mg to 2.4mg and the constipation got better, not worse

Metabranch of 6 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking maintenance against eGFR for 21 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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6 comments, started 4 months ago
u/aurel_mwangi27 points·4 months ago

regain after taper is expected, plan for it

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u/nabila_espinoza0 points·4 months ago

state how long you have been at maintenance, week 14 is not maintenance

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u/mass_spec_maggieMS1 point·4 months ago

regain is not a moral failing

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u/hedda_ekstrom1 point·4 months ago

regain is not a moral failing

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/aleksi_lehtinen1 point·4 months ago

the plateau is where the learning happens

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u/oskar_malinowski13 points·4 months ago

Mechanistically the bit that matters is lowest effective dose. It explains most of the early profile and a decent chunk of the outcome.

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The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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  1. State how long you have been at maintenance. "Maintenance" at week 30 is not maintenance.
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