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c/coldchain·posted 2 years ago by u/priya_weiss

anyone else notice lyophilised kicking in around week 80

Explainer Receipts ×4 Well Actually ×2 Cold Box ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking lyophilised against eGFR for 17 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

3,312 up / 649 down84% upvoted41 commentsid ua7zt024 Mar 2024

41 comments

20 in this archive, depth 4

best — the order this archive was captured in

u/plain_titration_2024393 points·2 years ago

Reconstituted or dry powder?

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u/nadia_kjaer116 points·2 years ago

the logger trace is the data that matters, not the packaging promises

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u/aleksi_eriksen308 points·2 years ago

Reconstituted or dry powder?

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u/priya_weissOP126 points·2 years ago

data logger is the standard, gut feeling is not

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u/ice_pack_auditcold chain59 points·2 years ago

France to France takes 4 days on average, variance is 36 days

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u/ms_fragmenter41 points·2 years ago

data logger is the standard, gut feeling is not

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u/bruno_dumitru-12 points·2 years ago

Not to be pedantic but excursion and packaging are being used interchangeably and they are not interchangeable in real life.

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u/emil_marchand213 points·2 years ago

I am going to push back on this slightly.

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u/osman_eriksen186 points·2 years ago·edited

This is correct. Dry powder is way more robust than liquid.

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u/osman_brandt46 points·2 years ago

This is correct.

Disagree on that part. 95.1% and 97.6% on the same vial is normal.

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u/anders_karlsen31 points·2 years ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/curious_panel_only122 points·2 years ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/ice_pack_auditcold chain33 points·2 years ago

Disagree. What you are describing is consistent with stability, not with what you concluded.

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u/preservative_free_p96 points·2 years ago

stability after excursion is not zero, it is dose-dependent

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u/bruno_dumitru114 points·2 years ago

The confident tone is doing a lot of work that the evidence is not.

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u/tidy_vialdrawer_watch2841 points·2 years ago

excursion claims need a logger trace or a photo at unboxing, not "it felt warm"

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[deleted]16 points·2 years ago

[deleted]

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u/ireland_drugs_pay53 points·2 years ago
post the spreadsheet
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u/hplc_hobbyistruns their own column18 points·2 years ago

data logger is the standard, gut feeling is not

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Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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