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c/coldchain·submitted 7 days ago by u/analog_alphabet

[Explainer] lyophilised powder is far more forgiving than you think

Explainerbranch of 7 comments

Confession thread, sort of. I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 6 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have early…

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7 comments, started 5 days ago
u/ferran_laurent28 points·5 days ago

The gel pack lasted 4 hours in a courier van, then liquid. Powder itself fine, the cold chain mostly died in transit.

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u/niels_norgaard10 points·5 days ago

I am going to push back on this slightly.

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u/search_before_post18 points·5 days ago

time-at-temperature integral is the dose, not just peak temperature

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u/lina_almeida17 points·5 days ago

That is net peptide content, not purity. Different number, different meaning.

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u/reship_roulette11 points·4 days ago

data logger is the standard, gut feeling is not

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u/osman_brandt14 points·4 days ago·edited

lyophilised powder is far more forgiving than reconstituted solution

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u/osman_eriksen9 points·4 days ago

This is correct. Dry powder is way more robust than liquid.

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Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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