u/matias_salgado
Contributes reviews on supplier material. Based in Mombasa.
member · joined 15 Jun 2025
Comments — page 4 of 4
comment on the SURPASS thing finally clicked for me and I want to write it down in c/tirzepatide · 112 points · 2 years ago
What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.
comment on three years of Mounjaro threads, summarised so you do not have to read them in c/tirzepatide · 20 points · 2 years ago
the appetite change on tirz is more than just reduced hunger, it is different machinery
comment on [Lab] 13th independent test on BCH, and the trend is the interesting part in c/tirzepatide · -13 points · 2 years ago
Crossposting this to c/glp1uk because the people who need it are not reading this community.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on [Lab] 16th independent test on BCH, and the trend is the interesting part in c/hplc · 1 points · 2 years ago
What was the column and what gradient?
comment on method development vs HPLC — genuinely asking which matters more in c/hplc · 29 points · 2 years ago
Mechanistically the bit that matters is method development.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on [Discussion] we are measuring Zepbound at the wrong time and calling it noise in c/tirzepatide · 15 points · 2 years ago
Sceptical. If this were true we would see it reflected in the data and we do not.
comment on [Results] 57 weeks, 20kg, and tirzepatide was the hard part in c/tirzepatide · 53 points · 2 years ago
SURMOUNT data is messier than STEP data but the weight loss is there
comment on why does nobody talk about method development in c/hplc · 2 points · 2 years ago
chromatogram or it did not happen
comment on dual agonist — 12 things I got wrong before I got it right in c/tirzepatide · 9 points · 2 years ago
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
comment on am I the only one who found integration harder than the injections in c/hplc · 21 points · 2 years ago
the gradient is doing the separation work, not the column alone
comment on [Vendor] QST order #6 — Denmark, 3 days, no drama, receipts inside in c/tirzepatide · 264 points · 2 years ago
dual agonism is SURPASS, do not generalise from semaglutide
comment on [Vendor] QST order #6 — Denmark, 3 days, no drama, receipts inside in c/tirzepatide · 234 points · 2 years ago
Small correction: the trial was 3 weeks, not 16. Does not change your point but people will quote it.
comment on tried tirzepatide for 15 weeks. here is what happened. in c/tirzepatide · 41 points · 2 years ago
the GIP side does different things than the GLP-1 side, that is the point
comment on tried tirzepatide for 15 weeks. here is what happened. in c/tirzepatide · 383 points · 2 years ago
The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.