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c/tirzepatide·submitted 28 days ago by u/nordic_pricing

[Question] does the vial concentration change how much dead space costs me

Questionbranch of 8 comments

Question in the title, detail here: does the vial concentration change how much dead space costs me. The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm. Sulphur burps for the first…

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8 comments, started 28 days ago
u/taper_off_tabitha42 points·28 days ago

Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.

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u/nordic_pricingOP26 points·28 days ago·edited

Research-use-only material is not approved for human use.

Saving this one. It is the clearest statement of the stall problem I have read here.

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u/graph_it_gary8 points·27 days ago

dual agonist, so the GIP arm is doing something the sema threads will not tell you about

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u/copay_card_cc4 points·27 days ago

Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.

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u/marta_dziedzic3 points·27 days ago

The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 24 is not a fair reading.

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u/samir_falk2 points·27 days ago

2.5 is the starter dose and it is not meant to be the dose that works

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u/fatima_wojcik7 points·27 days ago

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

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u/nordic_pricingOP5 points·27 days ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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