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c/tapering·submitted 9 months ago by u/marisol_kravchenko

discontinuation: what the trials say vs what this community says

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Genuinely asking, not being difficult. Everyone in c/progresspics repeats that tapering is important. I believe it, but I have never seen anyone show why, and when I search I get 5 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because…

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9 comments, started 9 months ago
u/rekha_teixeira157 points·9 months ago
reading this at 2am on my 44th week. thank you.
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u/coa_janitormod · c/coa51 points·9 months ago·edited

reading this at 2am on my 44th week.

Adding to this: appetite return is doing more work than the comment implies.

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[deleted]22 points·9 months ago

[deleted]

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u/marisol_kravchenkoOP121 points·9 months ago

The nausea was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/adaeze_weiss55 points·9 months ago

The nausea was genuinely awful for three weeks and then simply stopped.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/appeal_letter_al30 points·9 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/quiet_reader_9916 points·9 months ago

say how long you were on and at what dose before taper

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u/rekha_teixeira10 points·9 months ago

I am going to push back on this slightly.

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u/piotr_bruun77 points·9 months ago

the regain is treatment of chronic condition ending, not failure

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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