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c/tapering·submitted 8 months ago by u/yara_lindholm

[Question] discontinuation — what am I missing here

Questionbranch of 6 comments

Trying to settle this properly because the thread from last year went in circles. The claim: regain matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 22 months without either producing anything. What would actually settle it is 9 people measuring the same…

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6 comments, started 8 months ago
u/britta_boateng11 points·8 months ago

interval stretching versus dose reduction

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u/rekha_teixeira5 points·8 months ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/zeynep_villalobos2 points·8 months ago

cite the discontinuation data rather than guessing regain rates

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u/andres_restrepo7 points·8 months ago·edited

Stalled for 19 weeks, changed nothing, and it started moving again on week 62.

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u/yara_lindholmOP3 points·8 months ago

Stalled for 19 weeks, changed nothing, and it started moving again on week 62.

Yes, exactly this, and it is the bit that took me 28 weeks to accept.

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u/maren_baptista7 points·8 months ago

Respectfully this is a sample of one presented as a finding.

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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