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c/tapering·posted 1 months ago by u/lina_adebayo

[Meta] proposal — a flair for discontinuation posts

Trial Data Cold Box ×2

Right, the regain question again, but with numbers this time.

I have 21 data points over 8 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 69, not week 23. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

0 up / 0 down41% upvoted7 commentsid 1ew2ul3 Jun 2026

7 comments

7 in this archive, depth 4

best — the order this archive was captured in

u/ahmed_okafor5 points·1 months ago

Maintenance for 21 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/nabila_bakken4 points·1 months ago

You have restated the marketing copy. What is the actual substance here.

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u/malin_petrescu3 points·1 months ago

cite the discontinuation data rather than guessing regain rates

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u/katrin_diallo-10 points·1 months ago

cite the discontinuation data rather than guessing regain rates

Adding to this: interval stretching is doing more work than the comment implies.

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u/nabila_bakken1 point·1 months ago

cite the discontinuation data rather than guessing regain rates Adding to this: interval stretching is doing more work than the comment implies.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/vikram_asante1 point·1 months ago

This is correct. Discontinuation data is real.

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u/arne_restrepo1 point·1 months ago

regain on taper is expected, plan for it

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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