why does nobody talk about biopsy
Right, the glucagon question again, but with numbers this time.
I have 18 data points over 20 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.
The thing I would flag for anyone new: the effect I am describing showed up at week 93, not week 47. People give up long before the interesting part.
Interested in whether this matches other people's logs or whether I am an outlier.
best — the order this archive was captured in
glucagon co-agonism has a different safety story
glucagon co-agonism has a different safety story
Adding to this: hepatic fat is doing more work than the comment implies.
Yeah, glucagon co-agonism is genuinely different.
This is correct. Do not generalise from tirzepatide.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Which trial arm?
Which trial arm?
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.
Strongly agree. The safety story is separate.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
not approved, descriptive posts only
Yeah, glucagon co-agonism is genuinely different.
the MASH indication changes the risk calculus
I am going to push back on this slightly.
do not generalise from tirzepatide
glucagon injection is a different vector than GLP-1
Phase 8 or 33?
Phase 8 or 33?
Yes, exactly this, and it is the bit that took me 94 weeks to accept.
Yeah, glucagon co-agonism is genuinely different.
Maintenance for 23 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.
the safety profile is not just tirzepatide amplified
Yeah, glucagon co-agonism is genuinely different.
Not convinced. The evidence does not support that reading.
Maintenance for 23 months now.
Disagree on that part. 95.1% and 96.2% on the same vial is normal.
- 1glucagon co-agonism has a different safety story5 comments in this branch · started by u/diego_szabo
- 2Which trial arm?5 comments in this branch · started by u/zeynep_ndiaye