[Discussion] biopsy is doing more work than we give it credit for
Something I noticed reading old threads that I have not seen said out loud.
The advice on hepatic fat in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.
I have listed what I think the current consensus is below. Correct me — that is the point of posting it.
best — the order this archive was captured in
Tracking number removed. It identifies both ends of a shipment.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
this is the answer
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
Yeah, glucagon co-agonism is genuinely different.
Small correction: the trial was 23 weeks, not 22. Does not change your point but people will quote it.
That is net peptide content, not purity. Different number, different meaning.
Mechanistically the bit that matters is hepatic fat. It explains most of the early profile and a decent chunk of the outcome.
the MASH indication changes the risk calculus
MASH claims need the trial and the biopsy endpoint
Yeah, glucagon co-agonism is genuinely different.
Hepatic fat or MASH or what?
This is correct. Do not generalise from tirzepatide.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.
the heart rate signal is real in the data
phase 7 data is interesting, phase 6 will be different
Came off after 5 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.
My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
Not convinced. The evidence does not support that reading.
- 1this is the answer6 comments in this branch · started by u/clara_restrepo
- 2Mechanistically the bit that matters is hepatic fat. It explains most of the…5 comments in this branch · started by u/milan_mensah