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c/survodutide·submitted 1 year ago by u/renal_outcomes_r

[Question] how do you actually verify hepatic fat

Questionbranch of 13 comments

Week 94 update. 25kg down from the start, reflux basically gone since about week 39. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux. The part that surprised me is how much of this is admin. Ordering,…

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13 comments, started 1 year ago
u/liver_enzyme_lizMOD144 points·1 year ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/rafael_sjoberg74 points·1 year ago

Flair changed to match the content.

Yes, exactly this, and it is the bit that took me 58 weeks to accept.

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[deleted]47 points·1 year ago

[deleted]

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u/preservative_free_p19 points·1 year ago

glucagon injection is a different vector than GLP-1

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u/kaia_wojcik12 points·1 year ago·edited

glucagon co-agonism has a different safety story

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u/joaquin_ivaturi6 points·1 year ago

Strongly agree. The safety story is separate.

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u/mod_cold_roommod · c/coldchain7 points·1 year ago

the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1

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u/zeynep_villalobos33 points·1 year ago

hepatic fat and biopsy are the story

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u/liv_vukovic21 points·1 year ago

phase 11 data is interesting, phase 24 will be different

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u/rania_salinas18 points·1 year ago

Yeah, glucagon co-agonism is genuinely different.

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u/renal_outcomes_rOPnephro-curious55 points·1 year ago

The fatigue was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/renzo_asante-21 points·1 year ago

glucagon injection is a different vector than GLP-1

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u/renal_outcomes_rOPnephro-curious59 points·1 year ago

Which trial arm?

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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