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c/survodutide·submitted 6 days ago by u/thermal_mass_tom

[Trial Data] phase 2 biopsy endpoints, and what "resolution" means

Trial Databranch of 8 comments

Posting this because I searched for it and got nothing useful. Setup: 15mg, week 49, sulphur burps present but not ruining anything. I changed exactly one variable — biopsy — and tracked it for 12 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am…

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8 comments, started 5 days ago
u/incretin_ivypharmacology66 points·5 days ago

not approved, descriptive posts only

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u/incretin_ivyMOD36 points·5 days ago·edited

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/kasper_cabrera44 points·5 days ago·edited

Not convinced. The evidence does not support that reading.

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u/certified_referenceQC18 points·5 days ago

glucagon co-agonism has a different safety story

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u/dexa_twice_yearlybody comp4 points·4 days ago

the heart rate signal is real in the data

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u/andres_dahlberg29 points·5 days ago

Flair changed to match the content.

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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u/slow_logbook_notes3027 points·5 days ago

Not to be pedantic but survodutide and biopsy are being used interchangeably and they are not interchangeable in real life.

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u/thermal_mass_tomOP18 points·5 days ago·edited

Which trial arm?

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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