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c/sideeffects·posted 9 months ago by u/yannick_barros

constipation — 19 things I got wrong before I got it right

Discussion Clean Column ×5

Confession thread, sort of.

I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 21 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have constipation I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 61 reads it before doing the same thing.

899 up / 335 down73% upvoted34 commentsid gisf5p26 Oct 2025

34 comments

25 in this archive, depth 4

best — the order this archive was captured in

u/quiet_moderatorMOD117 points·9 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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[deleted]80 points·9 months ago

[deleted]

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u/food_noise_gonemaintenance33 points·9 months ago

How many weeks in are you? 12 weeks is noise, 31 weeks is a trend.

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u/yannick_barrosOP45 points·9 months ago

sulphur burps are disgusting but not dangerous, 8 weeks and they stopped

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u/yannick_barrosOP85 points·9 months ago

Went to A&E convinced it was pancreatitis. Lipase normal. It was gallstones. Get checked, do not post and wait.

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u/insulin_syringe_ian70 points·9 months ago

Did the fatigue start before or after the dose increase?

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u/hassan_castellanos27 points·9 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/zaid_balogun70 points·9 months ago

sulphur burps are disgusting but not dangerous, 8 weeks and they stopped

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u/graph_it_gary54 points·9 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/yannick_barros15 points·9 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points.

Yes, exactly this, and it is the bit that took me 78 weeks to accept.

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u/signe_villalobos51 points·9 months ago

resting heart rate moved up 4 bpm and settled back down when I stopped escalating

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u/isabela_nilsen35 points·9 months ago

Yeah, the fatigue hit on day 12 for me too, not day 1.

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u/nausea_notesside effects28 points·9 months ago

Yeah, the fatigue hit on day 12 for me too, not day 1.

Disagree on that part. 97.4% and 97.6% on the same vial is normal.

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u/yannick_barrosOP13 points·9 months ago

The muscle cramps was genuinely awful for three weeks and then simply stopped. Week 59 me did not think I would make it to week 10.

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u/gentle_correctionnice about it34 points·9 months ago·edited

Yeah, the muscle cramps hit on day 14 for me too, not day 1.

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u/constipation_clubside effects8 points·9 months ago

Yeah, the fatigue hit on day 19 for me too, not day 1.

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u/clara_weiss5 points·9 months ago·edited

IANAD and neither is anyone upvoting this

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u/zeynep_zielinski29 points·9 months ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/line_petrov6 points·9 months ago

early fullness at 2.4mg is different from 1.7mg

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u/mikkel_kimani3 points·9 months ago

sulphur burps are disgusting but not dangerous, 20 weeks and they stopped

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u/janoshik_junkieindependent tester24 points·9 months ago

The reflux was genuinely awful for three weeks and then simply stopped. Week 64 me did not think I would make it to week 24.

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u/signe_villalobos20 points·9 months ago

Not convinced. The evidence does not support that reading.

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u/janoshik_junkieindependent tester6 points·9 months ago

early fullness at 2.5mg is different from 2.4mg

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u/britt_abubakar16 points·9 months ago

resting heart rate moved up 10 bpm and settled back down when I stopped escalating

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u/ilias_cabrera13 points·9 months ago

How many weeks in are you? 21 weeks is noise, 25 weeks is a trend.

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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