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c/sideeffects·posted 6 months ago by u/zeynep_ndiaye

is it normal to get injection-site soreness at week 4

Management Receipts ×5

Something I noticed reading old threads that I have not seen said out loud.

The advice on sulphur burps in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

1,076 up / 364 down75% upvoted65 commentsid 1bvsz117 Jan 2026

65 comments

27 in this archive, depth 4

best — the order this archive was captured in

u/constipation_clubMOD111 points·6 months ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/placebo_arm_pam85 points·6 months ago·edited

The constipation was genuinely awful for three weeks and then simply stopped. Week 33 me did not think I would make it to week 45.

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u/reta_and_regret30 points·6 months ago

the food-noise thing stops around week 94 for most people

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u/ferran_krastev103 points·6 months ago·edited

Mechanistically the bit that matters is fatigue. It explains most of the early profile and a decent chunk of the outcome.

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u/placebo_arm_pam72 points·6 months ago

Strongly agree. Describe your dose, your week number, and your titration speed or nobody can help.

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u/zeynep_ndiayeOP43 points·6 months ago

Resting heart rate up 6 bpm from baseline, settled back down once I stopped escalating. Tracked daily so I am confident.

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u/coring_the_stopper46 points·6 months ago·edited

Crossposting this to c/vendorvetting because the people who need it are not reading this community.

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u/zeynep_ndiayeOP25 points·6 months ago

Has anything else changed? Sleep, food, protein, anything?

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u/thermal_mass_tom12 points·6 months ago

hair loss is real and usually reversible when you stabilize

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u/step_therapy_s3 points·6 months ago

resting heart rate moved up 15 bpm and settled back down when I stopped escalating

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u/slow_logbook_ftw23 points·6 months ago

Disagree. What you are describing is consistent with hair loss, not with what you concluded.

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u/thermal_mass_tom36 points·6 months ago·edited

Crossposting this to c/vendorvetting because the people who need it are not reading this community.

Adding to this: fatigue is doing more work than the comment implies.

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u/zeynep_zielinski23 points·6 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/aleksi_lehtinen14 points·6 months ago

The fatigue was genuinely awful for three weeks and then simply stopped. Week 43 me did not think I would make it to week 92.

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u/mikkel_kimani11 points·6 months ago

The fatigue was genuinely awful for three weeks and then simply stopped.

Yes, exactly this, and it is the bit that took me 37 weeks to accept.

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[deleted]5 points·6 months ago

[deleted]

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u/rania_diallo11 points·6 months ago

Slight fix: the number was 96.8, not 96.2. Decimal point, but a fairly consequential one.

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u/milan_villalobos12 points·6 months ago

Resting heart rate up 5 bpm from baseline, settled back down once I stopped escalating. Tracked daily so I am confident.

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u/blunt_coldbox_202410 points·6 months ago·edited

week 80 and the nausea is finally getting better

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u/ayesha_erdogan9 points·6 months ago

week 3 and the early fullness is finally getting better

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u/ferran_dahlberg4 points·6 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/blunt_coldbox_202418 points·6 months ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/chidi_demir14 points·6 months ago

Strongly agree. Describe your dose, your week number, and your titration speed or nobody can help.

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u/nabila_ogunleye11 points·6 months ago

the food-noise thing stops around week 76 for most people

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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