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c/reconstitution·submitted 3 months ago by u/rosa_mensah

[Discussion] the insulin syringe advice in here is 10 years out of date

Discussionbranch of 5 comments

I have had 18 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 30 days on nominally the same lane, which matters more in summer than in February. The independent number came back 93.7% against a claimed…

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5 comments, started 3 months ago
u/dilara_szabo496 points·3 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/lyophile_lou111 points·3 months ago

Dead space ate 17 units on a low-volume draw. Tiny impact at 1.7mg, massive impact at 2.4mg.

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u/aurel_boateng81 points·3 months ago

Small correction: the trial was 18 weeks, not 34. Does not change your point but people will quote it.

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u/priya_guerrero55 points·3 months ago

Dead space ate 17 units on a low-volume draw.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/oskar_ibarra23 points·3 months ago

dosing errors come from people reconstituting two vials differently and forgetting which is which

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The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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