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c/reconstitution·submitted 1 months ago by u/RetaAndRegret2

week 71 check-in — 6kg down, constipation manageable, one thing confusing me

Mathbranch of 10 comments

Genuinely asking, not being difficult. Everyone in c/orforglipron repeats that concentration is important. I believe it, but I have never seen anyone show why, and when I search I get 2 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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10 comments, started 1 months ago
u/wanjiru_varga78 points·1 months ago

Disagree. What you are describing is consistent with insulin syringe, not with what you concluded.

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u/ines_ekstrom22 points·1 months ago

u-100 syringe, not u-40, or your math is off by factor of 19

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u/RetaAndRegret2OP-2 points·1 months ago

Show the arithmetic. Where did the units come from?

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u/andres_sorensen1 point·1 months ago

dosing errors come from people reconstituting two vials differently and forgetting which is which

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u/hub_opssite staff55 points·1 months ago

This is correct. 2mL versus 2mL is the common mistake.

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u/RetaAndRegret2OP31 points·1 months ago

30mg vial, 2mL water, concentration is 30/2 — write it on the vial afterwards

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u/bac_water_banditreconstitution59 points·1 months ago

dead space is real and the syringe matters

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u/signe_grimaldi26 points·1 months ago

dead space is real and the syringe matters

Disagree on that part. 98.1% and 98.4% on the same vial is normal.

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u/honest_syringe_maybe8 points·1 months ago

Small correction: the trial was 15 weeks, not 23. Does not change your point but people will quote it.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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