unpopular opinion: purity is massively overrated
Been lurking in c/progresspics for about 15 months and finally have something worth posting.
Short version: week 81, 12.5mg, and gradient is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 27 threads, and the answers split roughly down the middle.
What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 75.
best — the order this archive was captured in
Mechanistically the bit that matters is chromatogram. It explains most of the early profile and a decent chunk of the outcome.
axis labels included, always
chromatogram or it did not happen
This is the correct method framing. Column and gradient are load-bearing fields.
Not convinced. The evidence does not support that reading.
area% and mass% are not the same and this whole post conflates them
This is the correct method framing. Column and gradient are load-bearing fields.
integration decision on a shoulder changes your number by half a point on its own
This is the correct method framing. Column and gradient are load-bearing fields.
Strongly agree. Largest single impurity tells a different story than total purity.
Flair changed to match the content. Read the sidebar before posting next time and we are square.
Yeah, the chromatogram profile matters more than the headline number.
Injection volume and flow rate? Those affect resolution.
- 1Mechanistically the bit that matters is chromatogram. It explains most of…9 comments in this branch · started by u/aksel_kjaer