u/two_mil_or_one

Week 4 for me and the honest summary is: 43kg down, reflux manageable, and I have thought about food maybe four times today.

the thymosin literature is thin on humans

Not convinced. The evidence does not support that reading.

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

Did you stay on semaglutide or switch?

Adding to this: dual agonist is doing more work than the comment implies.

The related substances profile is way more interesting than the main peak %. A 98% with 11 peaks is different from a 98% that is one 23% impurity.

The related substances profile is way more interesting than the main peak %. A 98% with 24 peaks is different from a 98% that is one 25% impurity.

co-elution is real and LC-MS is usually not enough to resolve it

Ran the same vial on two columns, different purity, both right, different separation. Method matters more than equipment.

Yeah, the chromatogram profile matters more than the headline number.

Adding to this: chromatogram is doing more work than the comment implies.

pens are overpriced, research vials are research grade, same molecule different price

Stalled at 0.25mg, changed nothing, and it started moving again on week 5. Very nearly went up. Glad I did not.

Respectfully this is a sample of one presented as a finding.

I am going to push back on this slightly.

chromatogram or it did not happen

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.