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c/tirzepatide·posted 2 years ago by u/marta_dziedzic

[Vendor] QST vs QYB on the same compound, same month — both cleared 99.0%

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Numbers in the title, numbers in the post. QST vs QYB on the same compound, same month — both cleared 99.0%.

To save the first four comments: 99.0%.

The step schedule question, answered properly, because it comes up weekly.

The label sets a minimum interval of four weeks between increases. That is a floor on how fast you may go, and it exists because tolerability, not efficacy, is what limits most people. There is nothing in the pharmacology that says you must increase at four weeks, or at eight, or ever.

What decides it in practice is whether the effect you want is still there. If appetite is quiet and the trend is going the right way, the dose is doing its job. If both have genuinely gone flat for six weeks or more, that is a conversation worth having with someone who knows your history.

Week 49 was the first time the scale moved after a five-week stall. I changed nothing in that window.

Tell me where this is wrong. That is the useful part of posting it.

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62 comments

22 in this archive, depth 4

best — the order this archive was captured in

u/swirl_dont_shakereconstitution1.4k points·2 years ago·edited

Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.

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u/ingrid_correia1.1k points·2 years ago

I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your food noise pattern is a guess.

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u/halima_boateng333 points·2 years ago

dual agonist, so the GIP arm is doing something the sema threads will not tell you about

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u/certified_referenceQC90 points·2 years ago

Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.

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u/ferran_mensah1.7k points·2 years ago

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

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u/rania_diallo795 points·2 years ago

Same experience with the appetite effect being flatter across the week rather than front-loaded.

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u/matias_salgado234 points·2 years ago

Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.

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u/fatima_wojcik254 points·2 years ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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u/amara_halonen533 points·2 years ago

What step are you on and how long have you been there?

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u/marta_dziedzicOP245 points·2 years ago

the trials titrated on a calendar, real people titrate on symptoms

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u/crosspost_bot_no135 points·2 years ago

What step are you on and how long have you been there?

This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.

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u/graph_it_gary46 points·2 years ago

This.

crosspost_bot_no is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

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u/ahmed_fonseca379 points·2 years ago·edited

Does constipation follow the day after the shot, or is it spread across the week?

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[removed]145 points·2 years ago

[removed by moderator]

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u/graph_it_gary73 points·2 years ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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u/samir_falk57 points·2 years ago

Not sure that follows. You went up a step and changed your training in the same fortnight.

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u/ferritin_low309 points·2 years ago

The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.

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u/alcohol_aversion152 points·2 years ago

switching from sema is not a dose conversion, there is no clean equivalence

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u/marta_dziedzicOP115 points·2 years ago

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

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Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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