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c/tapering·posted 23 days ago by u/aleksi_lehtinen

[Meta] the tapering rule is doing its job and people should stop complaining

Discussion Clean Column ×8

Posting this because I searched for it and got nothing useful.

Setup: 10mg, week 20, constipation present but not ruining anything. I changed exactly one variable — tapering — and tracked it for 14 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

565 up / 84 down87% upvoted31 commentsid ukpdh67 Jul 2026

31 comments

23 in this archive, depth 5

best — the order this archive was captured in

u/pavel_halvorsen36 points·22 days ago

Came off after 88 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/vial_math_verasyringe math13 points·21 days ago

Yeah, regain is not a failure.

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u/osman_eriksen17 points·21 days ago

Disagree. What you are describing is consistent with appetite return, not with what you concluded.

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u/maintenance_mode_maxMOD19 points·21 days ago·edited

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/careful_gradient0 points·21 days ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/rekha_teixeira19 points·21 days ago

This is correct. Discontinuation data is real.

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u/priya_weiss9 points·20 days ago·edited

the regain is treatment of chronic condition ending, not failure

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u/ignacio_silva5 points·20 days ago

Not convinced. The evidence does not support that reading.

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[removed]2 points·20 days ago

[removed by moderator]

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u/quarter_dose_queenlow and slow2 points·20 days ago

say how long you were on and at what dose before taper

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u/aleksi_lehtinenOP0 points·20 days ago

no shaming people who restart

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u/pavel_halvorsen0 points·20 days ago

This is correct. Discontinuation data is real.

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u/janek_ferrari5 points·20 days ago

Which country? Half the answers in this thread only apply in Germany.

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u/laila_delgado9 points·20 days ago

Came off after 71 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/camila_marchand3 points·20 days ago

the 15 week discontinuation arm is the data

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u/honest_syringe_20252 points·20 days ago

What was the batch number and which service?

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u/viktor_kirchner1 point·20 days ago

the regain is treatment of chronic condition ending, not failure

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u/andres_restrepo11 points·21 days ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/salma_vasquez4 points·21 days ago

Did anything else change in the same window?

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u/meera_oyelaran-1 point·21 days ago

the regain is treatment of chronic condition ending, not failure

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u/britta_boateng1 point·21 days ago

the regain is treatment of chronic condition ending, not failure

Yes, exactly this, and it is the bit that took me 84 weeks to accept.

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u/aleksi_lehtinen8 points·21 days ago

Genuine question — what concentration were you at?

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u/elin_varga6 points·21 days ago

regain on taper is expected, plan for it

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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