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c/tapering·submitted 7 days ago by u/camila_marchand

[Trial Data] what the STEP 4 and SURMOUNT-4 withdrawal arms actually showed

Trial Databranch of 4 comments

Confession thread, sort of. I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 3 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have early…

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4 comments, started 5 days ago
u/cormac_roos3 points·5 days ago

Half-life is about 168 hours, so steady state lands around week 18–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/lift_heavy_thingsresistance training1 point·5 days ago

interval stretching versus dose reduction

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u/taper_off_tabitha1 point·5 days ago

Half-life is about 168 hours, so steady state lands around week 18–5.

Adding to this: discontinuation is doing more work than the comment implies.

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u/lane_watchermod · logistics1 point·5 days ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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